Document Detail


Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module.
MedLine Citation:
PMID:  23150248     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Histone and DNA methyltransferases utilize S-adenosyl-L-methionine (SAM), a key intermediate of sulfur amino acid metabolism, as a donor of methyl group. SAM is biosynthesized by methionine adenosyltransferase (MAT) using two substrates, methionine and ATP. Three distinct forms of MAT (MATI, MATII and MATIII), encoded by two distinct genes (MAT1A and MAT2A), have been identified in mammals. MATII consists of α2 catalytic subunit encoded by MAT2A and β regulatory subunit encoded by MAT2B, but the physiological function of the β subunit is not clear. MafK is a member of Maf oncoproteins and functions as both transcription activator and repressor by forming diverse heterodimers to bind to DNA elements termed Maf recognition elements. Proteomics analysis of MafK-interactome revealed its interaction with both MATIIα and MATIIβ. They are recruited specifically to MafK target genes and are required for their repression by MafK and its partner Bach1. Because the catalytic activity of MATIIα is required for the MafK target gene repression, MATIIα is suggested to provide SAM locally on chromatin where it is recruited. One of the unexpected features of MATII is that MATIIα interacts with many chromatin-related proteins of diverse functions such as histone modification, chromatin remodeling, transcription regulation, and nucleo-cytoplasmic transport. MATIIα appears to generate multiple, heterogenous regulatory complexes where it provides SAM. Considering their function, the heterooligomer of MATIIα and β is named SAMIT (SAM-integrating transcription) module within their interactome where it serves SAM for nuclear methyltransferases.
Authors:
Kazuhiko Igarashi; Yasutake Katoh
Related Documents :
24667308 - Microrna319 positively regulates cold tolerance by targeting ospcf6 and ostcp21 in rice...
23851338 - Unraveling the molecular basis of temperature-dependent genetic regulation in penicilli...
23134568 - The tomato cis-prenyltransferase gene family.
24109758 - Systemes analysis of interactions between micrornas and genes in hepatocellular carcinoma.
21265998 - Virus-induced gene silencing can persist for more than 2 years and also be transmitte...
22618238 - Over-expression of stress protein-encoding genes helps clostridium acetobutylicum to ra...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  61     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  105-118     Citation Subset:  -    
Affiliation:
Department of Biochemistry and Center for Regulatory Epigenome and Diseases, Tohoku University School of Medicine, Seiryo 2-1, Sendai, 980-8575, Japan, igarashi@med.tohoku.ac.jp.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria.
Next Document:  Epigenetic Regulation of Male Germ Cell Differentiation.