Document Detail

Metabolic acidosis in sepsis.
MedLine Citation:
PMID:  20509840     Owner:  NLM     Status:  MEDLINE    
Metabolic acidosis is very common in critically ill septic patients. Acidosis may be a result of the underlying pathophysiology, but it also may be the result of the way in which those patients are managed. Chloride-associated acidosis is frequent and is potentially aggravated during fluid resuscitation. The severity of metabolic acidosis is associated with poor clinical outcomes; however, it remains uncertain whether or not there is a causal relationship between acidosis and the pathophysiology of septic syndromes. Several experimental findings have demonstrated the impact of acidosis modulation on the release of inflammatory mediators and cardiovascular function. Treatment of metabolic acidosis is based on control of the underlying process and support of organ dysfunction, although the use of intravenous chloride-poor balanced solutions seems an attractive option to prevent the worsening of metabolic acidosis during fluid resuscitation.
Alexandre Toledo Maciel; Danilo Teixeira Noritomi; Marcelo Park
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrine, metabolic & immune disorders drug targets     Volume:  10     ISSN:  2212-3873     ISO Abbreviation:  Endocr Metab Immune Disord Drug Targets     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-23     Completed Date:  2011-01-04     Revised Date:  2012-04-19    
Medline Journal Info:
Nlm Unique ID:  101269157     Medline TA:  Endocr Metab Immune Disord Drug Targets     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
Intensive Care Unit, Emergency Department, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil.
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MeSH Terms
Acidosis / metabolism*,  physiopathology*,  therapy
Fluid Therapy
Shock, Septic / metabolism*,  physiopathology*,  therapy

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