| Metaanalysis vs large clinical trials: which should guide our management? | |
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MedLine Citation:
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PMID: 19027095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Large, randomized clinical trials have long been considered the gold standard to guide clinical care. Metaanalysis is a type of analysis in which results of a number of randomized clinical trials are combined and a summary measure of effect for a given treatment is ascertained. The clinician in practice often is faced with a dilemma regarding the type of evidence that should be used to guide clinical practice; for many clinical problems, there are both randomized controlled trials and metaanalyses available. The cases of calcium and aspirin therapy for the prevention of preeclampsia afford an opportunity to explore the benefits and limitations of each type of study to guide clinical practice. We conclude that, when available, large randomized clinical trials should be used to guide clinical practice. |
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Authors:
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Christina M Scifres; Jay D Iams; Mark Klebanoff; George A Macones |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2008-11-21 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 200 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 484.e1-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Meta-Analysis as Topic* Practice Guidelines as Topic Pregnancy Pregnancy Complications / prevention & control*, therapy* Randomized Controlled Trials as Topic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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