Document Detail

Metaanalysis vs large clinical trials: which should guide our management?
MedLine Citation:
PMID:  19027095     Owner:  NLM     Status:  MEDLINE    
Large, randomized clinical trials have long been considered the gold standard to guide clinical care. Metaanalysis is a type of analysis in which results of a number of randomized clinical trials are combined and a summary measure of effect for a given treatment is ascertained. The clinician in practice often is faced with a dilemma regarding the type of evidence that should be used to guide clinical practice; for many clinical problems, there are both randomized controlled trials and metaanalyses available. The cases of calcium and aspirin therapy for the prevention of preeclampsia afford an opportunity to explore the benefits and limitations of each type of study to guide clinical practice. We conclude that, when available, large randomized clinical trials should be used to guide clinical practice.
Christina M Scifres; Jay D Iams; Mark Klebanoff; George A Macones
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2008-11-21
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  200     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484.e1-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
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MeSH Terms
Meta-Analysis as Topic*
Practice Guidelines as Topic
Pregnancy Complications / prevention & control*,  therapy*
Randomized Controlled Trials as Topic*

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