Document Detail


Meta-study on association between the monoamine oxidase A gene (MAOA) and schizophrenia.
MedLine Citation:
PMID:  17894408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human monoamine oxidase A gene (MAOA) has attracted considerable attention as a candidate gene for schizophrenia based both on its chromosomal position and its enzyme function as a key factor in neurotransmitter catabolism pathways. However studies to date have reported inconsistent findings regarding the association between the variable number tandem repeat (VNTR) and T941G polymorphisms and schizophrenia. In an attempt to clarify this inconsistency we conducted a meta-analysis based on both alleles and genotypes (up to February 2006). In this study, however, we found no significant evidence of association with the two schizophrenia susceptibility polymorphisms.
Authors:
Dawei Li; Lin He
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  147B     ISSN:  1552-485X     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-05-07     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc
Affiliation:
Bio-X Center, Shanghai Jiao Tong University, Shanghai, China. dli@rockefeller.edu
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MeSH Terms
Descriptor/Qualifier:
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Monoamine Oxidase / genetics*
Polymorphism, Genetic
Schizophrenia / genetics*
Grant Support
ID/Acronym/Agency:
MH44292/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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