Document Detail

Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux.
MedLine Citation:
PMID:  15825565     Owner:  NLM     Status:  MEDLINE    
We report a meta-analysis of a series of studies in which 24-hour ambulatory pH monitoring was performed in 1) normal subjects, 2) the normal control subjects in studies of laryngopharyngeal reflux (LPR), and 3) the patients with LPR in these controlled studies. The statistical analysis utilized the fixed-effects model by Mantel-Haenszel and the random-effects mixed model. There were 16 studies from the past 12 years that fulfilled the inclusion criteria. They involved 793 subjects (264 normal and 529 with LPR). The numbers of positive pharyngeal reflux events for normal subjects and for patients with LPR differed with a p value of <.0001. There was also a significant difference in the mean percentage of acid exposure times between normal subjects and patients with LPR (p = .003). We conclude that the upper probe gives accurate and consistent information in normal subjects and patients with LPR. The numbers of reflux events and acid exposure times are most important in distinguishing normal subjects from patients with LPR. The technology and methodology of probe testing is quite reliable and is consistent on a worldwide basis.
Albert L Merati; Hyun J Lim; Seckin O Ulualp; Robert J Toohill
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  114     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-05-03     Revised Date:  2006-05-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  AIM; IM    
Department of Otolaryngology and Communication Sciences and the Division of Biostatistics, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0099, USA.
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MeSH Terms
Case-Control Studies
Gastroesophageal Reflux / diagnosis*
Hydrogen-Ion Concentration
Laryngeal Diseases / diagnosis*
Monitoring, Ambulatory / methods*
Pharyngeal Diseases / diagnosis*

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