Document Detail

Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.
MedLine Citation:
PMID:  20491052     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma.
METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been ≥2 weeks with ≥19 patients per treatment arm for a crossover, and ≥50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves.
RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p≤0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p≤0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05).
CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.
Princeton Wen-Yuan Lee; Aoife Doyle; Jeanette A Stewart; Caroline J Kristoffersen; William C Stewart
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  20     ISSN:  1724-6016     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1035-41     Citation Subset:  IM    
Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
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MeSH Terms
Administration, Topical
Adrenergic beta-Antagonists / administration & dosage*
Blood Pressure / drug effects*,  physiology
Circadian Rhythm / drug effects*,  physiology
Glaucoma, Open-Angle / drug therapy*,  physiopathology
Intraocular Pressure / drug effects*,  physiology
Ocular Hypertension / drug therapy,  physiopathology
Ophthalmic Solutions / administration & dosage
Randomized Controlled Trials as Topic
Timolol / administration & dosage*
Tonometry, Ocular
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Ophthalmic Solutions; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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