| Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure. | |
| | |
MedLine Citation:
|
PMID: 20491052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been ≥2 weeks with ≥19 patients per treatment arm for a crossover, and ≥50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p≤0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p≤0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours. |
| | |
Authors:
|
Princeton Wen-Yuan Lee; Aoife Doyle; Jeanette A Stewart; Caroline J Kristoffersen; William C Stewart |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: European journal of ophthalmology Volume: 20 ISSN: 1724-6016 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2010 Nov-Dec |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
|
Languages: eng Pagination: 1035-41 Citation Subset: IM |
Affiliation:
|
Royal Victoria Eye and Ear Hospital, Dublin, Ireland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Adrenergic beta-Antagonists / administration & dosage* Blood Pressure / drug effects*, physiology Circadian Rhythm / drug effects*, physiology Glaucoma, Open-Angle / drug therapy*, physiopathology Humans Intraocular Pressure / drug effects*, physiology Ocular Hypertension / drug therapy, physiopathology Ophthalmic Solutions / administration & dosage Randomized Controlled Trials as Topic Timolol / administration & dosage* Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Ophthalmic Solutions; 26839-75-8/Timolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systemic cyclosporin A in severe atopic keratoconjunctivitis.
Next Document: Ultrasound-assisted dispersive liquid-liquid microextraction coupled with capillary gas chromatograp...