Document Detail


Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect.
MedLine Citation:
PMID:  23321625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19,713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r=0.42; P-value=3.60 × 10(-61)) than father-offspring correlation (r=0.33; P-value=7.01 × 10(-5)), and a significant positive association with paternal age at offspring birth (β=0.005; P-value=7.01 × 10(-5)). Interestingly, a significant and quite substantial correlation in TL between spouses (r=0.25; P-value=2.82 × 10(-30)) was seen, which appeared stronger in older spouse pairs (mean age ≥55 years; r=0.31; P-value=4.27 × 10(-23)) than in younger pairs (mean age<55 years; r=0.20; P-value=3.24 × 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.
Authors:
Linda Broer; Veryan Codd; Dale R Nyholt; Joris Deelen; Massimo Mangino; Gonneke Willemsen; Eva Albrecht; Najaf Amin; Marian Beekman; Eco J C de Geus; Anjali Henders; Christopher P Nelson; Claire J Steves; Margie J Wright; Anton J M de Craen; Aaron Isaacs; Mary Matthews; Alireza Moayyeri; Grant W Montgomery; Ben A Oostra; Jacqueline M Vink; Tim D Spector; P Eline Slagboom; Nicholas G Martin; Nilesh J Samani; Cornelia M van Duijn; Dorret I Boomsma
Related Documents :
7641705 - Sources of variability in the human lymphocyte micronucleus assay: a population-based s...
19531355 - Effects of age on meiosis in budding yeast.
24310125 - Chemical investigations of wolf (canis lupus) anal-sac secretion in relation to breedin...
12798425 - Calcium and potassium currents in cells from adult and aged canine right atria.
15694735 - New forensic anthropological approachment for the age determination of human fetal skel...
22697255 - Bioaccumulation dynamics and modeling in an estuarine invertebrate following aqueous ex...
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2013-01-16
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  21     ISSN:  1476-5438     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-19     Completed Date:  2014-05-01     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  1163-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Inheritance Patterns
Male
Middle Aged
Paternal Age*
Pedigree*
Telomere / genetics*
Telomere Shortening / genetics*
Twins / genetics
Grant Support
ID/Acronym/Agency:
//British Heart Foundation; //Department of Health; //Wellcome Trust
Comments/Corrections
Comment In:
Eur J Hum Genet. 2014 Jan;22(1):10-1   [PMID:  24149546 ]
Eur J Hum Genet. 2014 Jan;22(1):8-9   [PMID:  24022299 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound finding...
Next Document:  Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is benefici...