Document Detail

Meta-analysis and systematic review of colorectal endoscopic mucosal resection.
MedLine Citation:
PMID:  19750569     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the proportion of successful complete cure en-bloc resections of large colorectal polyps achieved by endoscopic mucosal resection (EMR).
METHODS: Studies using the EMR technique to resect large colorectal polyps were selected. Successful complete cure en-bloc resection was defined as one piece margin-free polyp resection. Articles were searched for in Medline, Pubmed, and the Cochrane Control Trial Registry, among other sources.
RESULTS: An initial search identified 2620 reference articles, from which 429 relevant articles were selected and reviewed. Data was extracted from 25 studies (n = 5221) which met the inclusion criteria. All the studies used snares to perform EMR. Pooled proportion of en-bloc resections using a random effect model was 62.85% (95% CI: 51.50-73.52). The pooled proportion for complete cure en-bloc resections using a random effect model was 58.66% (95% CI: 47.14-69.71). With higher patient load (> 200 patients), this complete cure en-bloc resection rate improves from 44.19% (95% CI: 24.31-65.09) to 69.17% (95% CI: 51.11-84.61).
CONCLUSION: EMR is an effective technique for the resection of large colorectal polyps and offers an alternative to surgery.
Srinivas R Puli; Yasuo Kakugawa; Takuji Gotoda; Daphne Antillon; Yutaka Saito; Mainor R Antillon
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-09-30     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4273-7     Citation Subset:  IM    
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MeSH Terms
Colonic Polyps / surgery*
Colorectal Neoplasms / surgery*
Endoscopy, Gastrointestinal* / statistics & numerical data
Gastric Mucosa / surgery*
Precancerous Conditions / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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