Document Detail


Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure.
MedLine Citation:
PMID:  15617990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A systematic revision of the literature was conducted in order to undertake a comprehensive meta-analysis of all published observational studies on melanoma. An extensive analysis of the inconsistencies and variability in the estimates was performed to provide some clues about its Epidemiology. Following a systematic literature search, relative risks (RRs) for sun exposure were extracted from 57 studies published before September 2002. Intermittent sun exposure and sunburn history were shown to play considerable roles as risk factors for melanoma, whereas a high occupational sun exposure seemed to be inversely associated to melanoma. The country of study and adjustment of the estimates adjuste for phenotype and photo-type were significantly associated with the variability of the intermittent sun exposure estimates (P = 0.024, 0.003 and 0.030, respectively). For chronic sun exposure, inclusion of controls with dermatological diseases and latitude resulted in significantly different data (P = 0.05 and 0.031, respectively). Latitude was also shown to be important (P = 0.031) for a history of sunburn; studies conducted at higher latitudes presented higher risks for a history of sunburns. Role of country, inclusion of controls with dermatological diseases and other study features seemed to suggest that "well conducted" studies supported the intermittent sun exposure hypothesis: a positive association for intermittent sun exposure and an inverse association with a high continuous pattern of sun exposure.
Authors:
Sara Gandini; Francesco Sera; Maria Sofia Cattaruzza; Paolo Pasquini; Orietta Picconi; Peter Boyle; Carmelo Francesco Melchi
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  41     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-60     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, European Institute of Oncology, IRCCS Via Ripamonti 435, 20141 Milan, Italy. sara.gandini@ieo.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Child
Chronic Disease
Cohort Studies
Humans
Melanoma / etiology*
Middle Aged
Neoplasms, Radiation-Induced / etiology*
Risk Factors
Skin Neoplasms / etiology*
Sunburn / complications
Sunlight / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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