Document Detail

Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi.
MedLine Citation:
PMID:  15617989     Owner:  NLM     Status:  MEDLINE    
A systematic meta-analysis of observational studies of melanoma and one of the most important risk factors, the number of naevi, was conducted in order to clarify aspects of the aetiology of this disease. Following a systematic literature search, relative risks (RRs) were extracted from 46 studies published before September 2002. Dose-response random effects models were used to obtain pooled estimates. Sub-group analysis and meta-regression were carried out to explore sources of between-study variation and bias. Sensitivity analyses investigated the reliability of the results and any publication bias. Number of common naevi was confirmed an important risk factor with a substantially increased risk associated with the presence of 101-120 naevi compared with <15 (pooled Relative Risk (RR) = 6.89; 95% Confidential Interval (CI): 4.63, 10.25) as was the number of atypical naevi (RR = 6.36 95%; CI: 3.80, 10.33; for 5 versus 0). The type of study and source of cases and controls were two study characteristics that significantly influenced the estimates. Case-control studies, in particular when the hospital was the source for cases or controls, appeared to present much lower and more precise estimates than cohort studies.
Sara Gandini; Francesco Sera; Maria Sofia Cattaruzza; Paolo Pasquini; Damiano Abeni; Peter Boyle; Carmelo Francesco Melchi
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  41     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-44     Citation Subset:  IM    
Department of Epidemiology and Biostatistics, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
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MeSH Terms
Case-Control Studies
Cohort Studies
Dysplastic Nevus Syndrome / etiology,  pathology*
Melanoma / etiology,  pathology*
Nevus / etiology,  pathology*
Risk Assessment
Risk Factors
Skin Neoplasms / etiology,  pathology*

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