| Meta-analysis of the relationship of mycotoxins with biochemical and hematological parameters in broilers. | |
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MedLine Citation:
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PMID: 22252351 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A meta-analysis was carried out to study the association of mycotoxins with hematological and biochemical profiles in broilers. Ninety-eight articles published between 1980 and 2009 were used in the database, totaling 37,371 broilers. The information was selected from the Materials and Methods and Results sections in the selected articles and then tabulated in a database. Meta-analysis followed 3 sequential analyses: graphic, correlation, and variance-covariance. Mycotoxins reduced (P < 0.05) the hematocrit (-5%), hemoglobin (-15%), leukocytes (-25%), heterophils (-2%), lymphocytes (-2%), uric acid (-31%), creatine kinase (-27%), creatinine (-23%), triglycerides (-39%), albumin (-17%), globulin (-1%), total cholesterol (-14%), calcium (-5%), and inorganic phosphorus (-12%). Mycotoxins also altered (P < 0.05) the concentrations of alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. A quadratic effect was observed on the relationship between the concentration of aflatoxin in diets and the serum concentration of alkaline phosphatase, γ-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase. The total protein concentration in blood was 18% lower (P < 0.05) in broilers challenged by aflatoxins compared with that of the unchallenged ones. The inclusion of antimycotoxin additives in diets with aflatoxins altered (P < 0.05) some variables (uric acid, creatinine, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase) in relation to the group that received diets with the mycotoxin and without the additive. The meta-analysis performed in this study allowed us to address and quantify systematically the relationship of mycotoxins with alterations in hematologic and biochemical profiles in broilers. |
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Authors:
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I Andretta; M Kipper; C R Lehnen; P A Lovatto |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Poultry science Volume: 91 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: United States |
Other Details:
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Languages: eng Pagination: 376-82 Citation Subset: IM |
Affiliation:
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Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900 Brazil. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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