Document Detail

Meta-analysis of phenobarbital usage for prevention of intraventricular hemorrhage in premature infants: factors related to variation in outcome.
MedLine Citation:
PMID:  10150225     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the efficacy of phenobarbital for the prevention of intraventricular hemorrhage (IVH) in premature infants and to identify study characteristics that were associated with beneficial or adverse effects. DATA IDENTIFICATION: Studies published from 1981 to 1994 were identified through a computerized search, and by searching the bibliographies of all identified articles. STUDY SELECTION: Ten randomized, controlled clinical trials were selected. DATA EXTRACTION: Data were extracted from each article, including the percentage of patients in the control and treatment groups with IVH, and key patient and study characteristics. RESULTS OF DATA ANALYSIS: Seven studies showed no statistically significant effects, two studies showed a beneficial effect of phenobarbital, and one study showed an adverse effect. The meta-analysis showed no significant difference in the percentage of IVH in treated and untreated infants when treatment effects were combined across all studies. However, prenatal administration of phenobarbital in two studies was associated with a beneficial effect. CONCLUSIONS: Overall, we did not find a significant beneficial effect of postnatal phenobarbital administration. The data suggests that prenatal phenobarbital is beneficial. Further evaluations of the efficacy of prenatal phenobarbital are warranted.
D A Tholl; T Q Miller; W G Henderson; T F Myers
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Clinical trials and meta-analysis     Volume:  29     ISSN:  0927-5401     ISO Abbreviation:  Clin Trials Metaanal     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-06-05     Completed Date:  1995-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9212070     Medline TA:  Clin Trials Metaanal     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  177-90     Citation Subset:  T    
Department of Pharmacy, Loyola University Medical Center, Maywood, IL 60153, USA.
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MeSH Terms
Birth Weight
Cerebral Hemorrhage / prevention & control*
Cerebral Ventricles
Double-Blind Method
Gestational Age
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / prevention & control*
Maternal-Fetal Exchange
Odds Ratio
Phenobarbital / administration & dosage,  therapeutic use*
Pneumothorax / etiology
Positive-Pressure Respiration
Randomized Controlled Trials as Topic
Treatment Outcome
Reg. No./Substance:
0/Placebos; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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