Document Detail


Meta-analysis of observational studies on cholecystectomy and the risk of colorectal adenoma.
MedLine Citation:
PMID:  22410713     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: Cholecystectomy has been suggested as a risk factor for colorectal cancer. However, the association of cholecystectomy and the risk of colorectal adenoma (CRA) remains unclear. We conducted a meta-analysis of observational studies to explore this relationship.
METHODS: We identified studies by a literature search of MEDLINE and EMBASE through 30 September 2011, and by searching the reference lists of pertinent articles. Summary relative risks (SRRs) with their 95% confidence intervals (CIs) were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I.
RESULTS: A total of 10 studies (including 4061 CRA cases) were included in this meta-analysis. Analysis of these 10 studies found that no effect of cholecystectomy on the risk of CRAs was shown (SRR, 1.17; 95% CI: 0.93-1.48), with no significant heterogeneity among these studies (Pheterogeneity=0.106, I=37.9%). This null association was seen in both men and women (men: SRR=1.00, 95% CI: 0.58-1.73; women: SRR=1.39, 95% CI: 0.95-2.04).
CONCLUSION: The results of this meta-analysis suggest that there is no positive association between previous cholecystectomy and the risk of CRA development in both men and women.
Authors:
Chengjin Zhao; Zhenming Ge; Yamin Wang; Junbo Qian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  24     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, First People's Hospital of Nantong, Jiangsu, China.
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