Document Detail


Meta-analysis of medical treatment and placebo treatment for preventing postoperative recurrence in Crohn's disease (CD).
MedLine Citation:
PMID:  19172283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We performed a meta-analysis to compare the clinical and endoscopic recurrence of medical treatment and placebo treatment for preventing postoperative recurrence in Crohn's disease. MATERIALS AND METHODS: Trials were located through Medline, Embase, the Cochrane Central Register of Controlled Trials, Ovid, Sciencedirect, and Ingenta electronic databases. From 124 articles screened, 14 were identified as randomized placebo-controlled trials and were included for data extraction. Main outcome measures were clinical recurrence, endoscopic recurrence, and severe endoscopic recurrence. The meta-analysis was performed with the fixed-effects model. RESULT: Fourteen studies with 1,497 participants were analyzed. In the intention-to-treat analysis, medical treatment was associated with a significantly lower incidence of clinical recurrence (relative risk of 0.74, 95% confidence interval 0.64-0.87, P = 0.000], but there were no significant differences in endoscopic recurrence (0.94, 0.83-1.07, P = 0.353) and severe endoscopic recurrence (0.83, 0.60-1.16, P = 0.281) between the two groups. When using per-protocol analysis, the results is similar, medical treatment was associated with a significantly lower incidence of clinical recurrence (0.84, 0.72-0.97, P = 0.020), but there were no significant differences in endoscopic recurrence (0.94, 0.85-1.05, P = 0.268) or severe endoscopic recurrence (0.76, 0.55-1.04, P = 0.084) between the two groups of patients. CONCLUSIONS: Medical treatment has a sufficiently beneficial effect on decreasing the risk of clinical postoperative recurrence in patients with CD.
Authors:
Yunfei Cao; Feng Gao; Cun Liao; Aihua Tan; Zengnan Mo
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2009-01-27
Journal Detail:
Title:  International journal of colorectal disease     Volume:  24     ISSN:  1432-1262     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-26     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  509-20     Citation Subset:  IM    
Affiliation:
Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Guangxi, China.
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MeSH Terms
Descriptor/Qualifier:
Crohn Disease / drug therapy*,  prevention & control*,  surgery
Endoscopy
Humans
Placebos
Postoperative Period
Publication Bias
Randomized Controlled Trials as Topic
Recurrence / prevention & control
Treatment Outcome
Chemical
Reg. No./Substance:
0/Placebos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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