Document Detail


Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection.
MedLine Citation:
PMID:  20878943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The effectiveness of intraoperative povidone-iodine (PVI) application in the reduction of surgical-site infection (SSI) remains controversial. This meta-analysis was performed to assess the effect of intraoperative PVI application compared with no antiseptic solution (saline or nothing) on the SSI rate.
METHODS: The meta-analysis included randomized controlled trials that compared intraoperative PVI lavage with no PVI in patients undergoing surgery with SSI as the primary outcome. A fixed-effects or random-effects model was used as appropriate, and heterogeneity was assessed by the Cochran Q and the I(2) value.
RESULTS: Twenty-four randomized controlled trials totalling 5004 patients (2465 patients with PVI and 2539 patients without) were included: 15 in the main analysis and nine in the sensitivity analysis. The rate of SSI was 8.0 per cent in the PVI group and 13.4 per cent in the control group. Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) and consistent results were observed in subgroup analyses according to the method of PVI administration, its timing and the type of surgery.
CONCLUSION: The meta-analysis results suggested that the use of intraoperative PVI reduced rates of SSI.
Authors:
I Fournel; M Tiv; M Soulias; C Hua; K Astruc; L S Aho Glélé
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  The British journal of surgery     Volume:  97     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-28     Revised Date:  2011-06-10    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1603-13     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd
Affiliation:
Hospital Hygiene and Epidemiology Unit, Hôpital du Bocage, BP 77908, 21079 Dijon Cedex, France. isabellefournel@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / therapeutic use*
Humans
Intraoperative Care / methods*
Povidone-Iodine / therapeutic use*
Randomized Controlled Trials as Topic
Surgical Wound Infection / prevention & control*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 25655-41-8/Povidone-Iodine
Comments/Corrections
Comment In:
Br J Surg. 2011 Apr;98(4):602-3; author reply 603   [PMID:  21656730 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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