Document Detail

Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures.
MedLine Citation:
PMID:  8634613     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the ability of measurements of bone density in women to predict later fractures. DESIGN: Meta-analysis of prospective cohort studies published between 1985 and end of 1994 with a baseline measurement of bone density in women and subsequent follow up for fractures. For comparative purposes, we also reviewed case control studies of hip fractures published between 1990 and 1994. SUBJECTS: Eleven separate study populations with about 90,000 person years of observation time and over 2000 fractures. MAIN OUTCOME MEASURES: Relative risk of fracture for a decrease in bone mineral density of one standard deviation below age adjusted mean. RESULTS: All measuring sites had similar predictive abilities (relative risk 1.5 (95% confidence interval 1.4 to 1.6)) for decrease in bone mineral density except for measurement at spine for predicting vertebral fractures (relative risk 2.3 (1.9 to 2.8)) and measurement at hip for hip fractures (2.6 (2.0 to 3.5)). These results are in accordance with results of case-control studies. Predictive ability of decrease in bone mass was roughly similar to (or, for hip or spine measurements, better than) that of a 1 SD increase in blood pressure for stroke and better than a 1 SD increase in serum cholesterol concentration for cardiovascular disease. CONCLUSIONS: Measurements of bone mineral density can predict fracture risk but cannot identify individuals who will have a fracture. We do not recommend a programme of screening menopausal women for osteoporosis by measuring bone density.
D Marshall; O Johnell; H Wedel
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  312     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-08     Completed Date:  1996-07-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1254-9     Citation Subset:  AIM; IM    
Swedish Council on Technology Assessment in Health Care, Stockholm, Sweden.
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MeSH Terms
Bone Density*
Cohort Studies
Follow-Up Studies
Fractures, Bone / etiology*,  physiopathology
Hip Fractures / etiology,  physiopathology
Osteoporosis, Postmenopausal / complications,  physiopathology*
Predictive Value of Tests
Prospective Studies
Risk Factors
Sensitivity and Specificity
Comment In:
ACP J Club. 1996 Sep-Oct;125(2):48
BMJ. 1996 Aug 31;313(7056):561-2   [PMID:  8790008 ]
BMJ. 1996 Aug 31;313(7056):561   [PMID:  8790007 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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