Document Detail


Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
MedLine Citation:
PMID:  21572416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.
Authors:
Norihiro Kato; Fumihiko Takeuchi; Yasuharu Tabara; Tanika N Kelly; Min Jin Go; Xueling Sim; Wan Ting Tay; Chien-Hsiun Chen; Yi Zhang; Ken Yamamoto; Tomohiro Katsuya; Mitsuhiro Yokota; Young Jin Kim; Rick Twee Hee Ong; Toru Nabika; Dongfeng Gu; Li-Ching Chang; Yoshihiro Kokubo; Wei Huang; Keizo Ohnaka; Yukio Yamori; Eitaro Nakashima; Cashell E Jaquish; Jong-Young Lee; Mark Seielstad; Masato Isono; James E Hixson; Yuan-Tsong Chen; Tetsuro Miki; Xueya Zhou; Takao Sugiyama; Jae-Pil Jeon; Jian Jun Liu; Ryoichi Takayanagi; Sung Soo Kim; Tin Aung; Yun Ju Sung; Xuegong Zhang; Tien Yin Wong; Bok-Ghee Han; Shotai Kobayashi; Toshio Ogihara; Dingliang Zhu; Naoharu Iwai; Jer-Yuarn Wu; Yik Ying Teo; E Shyong Tai; Yoon Shin Cho; Jiang He
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-15
Journal Detail:
Title:  Nature genetics     Volume:  43     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-07-26     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asian Continental Ancestry Group / genetics*
Blood Pressure / genetics*
Diastole / genetics
European Continental Ancestry Group / genetics
Far East
Gene Frequency
Genome-Wide Association Study*
Humans
Polymorphism, Single Nucleotide
Systole / genetics
Grant Support
ID/Acronym/Agency:
K12HD043451/HD/NICHD NIH HHS; R01 HL087263/HL/NHLBI NIH HHS; R01 HL087263-01/HL/NHLBI NIH HHS; R01 HL087263-02/HL/NHLBI NIH HHS; R01 HL087263-02W1/HL/NHLBI NIH HHS; R01 HL087263-03/HL/NHLBI NIH HHS; R01 HL087263-04/HL/NHLBI NIH HHS; R01 HL087263-05/HL/NHLBI NIH HHS; R01 HL090682/HL/NHLBI NIH HHS; R01 HL090682-01A1/HL/NHLBI NIH HHS; R01 HL090682-01A1W1/HL/NHLBI NIH HHS; R01 HL090682-02/HL/NHLBI NIH HHS; R01 HL090682-03/HL/NHLBI NIH HHS; R01 HL090682-04/HL/NHLBI NIH HHS; R01HL087263/HL/NHLBI NIH HHS; R01HL090682/HL/NHLBI NIH HHS; U01 HL072507/HL/NHLBI NIH HHS; U01 HL072507-01/HL/NHLBI NIH HHS; U01 HL072507-02/HL/NHLBI NIH HHS; U01 HL072507-03/HL/NHLBI NIH HHS; U01 HL072507-03S1/HL/NHLBI NIH HHS; U01 HL072507-04/HL/NHLBI NIH HHS; U01 HL072507-04S1/HL/NHLBI NIH HHS; U01 HL072507-05/HL/NHLBI NIH HHS; U01 HL072507-06/HL/NHLBI NIH HHS; U01HL072507/HL/NHLBI NIH HHS
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