| Meta-analysis of epidemiologic dose-response data. | |
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MedLine Citation:
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PMID: 8512986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We discuss methods for summarizing epidemiologic studies of dose-response. The data from such a study typically appear as a series of dose-specific relative risks, with one category serving as the common reference group. We present methods for estimating the dose-response parameters from single and multiple study reports, for assigning levels to exposure categories when modeling relative risks, and for investigating the effects of study design and subject characteristics on dose-response curves. Finally, we discuss the choice of fixed vs random effects models. We illustrate our points with data from case-control studies of the relation between duration of oral contraceptive use and risk of breast cancer. |
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Authors:
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J A Berlin; M P Longnecker; S Greenland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 4 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-20 Completed Date: 1993-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 218-28 Citation Subset: IM |
Affiliation:
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Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6095. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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epidemiology Breast Neoplasms / epidemiology Case-Control Studies Contraceptives, Oral / administration & dosage Dose-Response Relationship, Drug* Epidemiologic Methods* Female Humans Meta-Analysis as Topic* Models, Biological Odds Ratio Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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