Document Detail

Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia.
MedLine Citation:
PMID:  18403735     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Recent reports have described the efficacy of the hematopoietic growth factor granulocyte-colony stimulating factor (G-CSF) in animal stroke models. Early clinical multicenter trials evaluating the effect of G-CSF in acute stroke and pilot clinical trials for the subacute phase are ongoing. To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits. METHODS: Using electronic and manual searches of the literature, we identified studies describing the efficacy of G-CSF in animal models of focal cerebral ischemia. Two reviewers independently selected studies and extracted data on study quality, G-CSF doses, time of administration, and outcome measured as infarct volume and/or sensorimotor deficit. Data from all studies were pooled by meta-regression analyses. RESULTS: Thirteen studies including 277 animals for infarct size calculation and 258 animals for assessment of sensorimotor deficit met the criteria for inclusion. Overall efficacy of G-CSF regarding infarct size reduction was 42%. Meta-regression analysis revealed a 0.8% (P<0.0001) decrease in infarct size per 1-mug/kg increase in G-CSF dose when applied within the first 6 hours and a 2.1% (P<0.0001) decrease when applied later than 6 hours after induction of ischemia with a significant (P=0.0004) greater infarct size reduction after delayed treatment. Sensorimotor deficits categorized into 3 subgroups improved between 24% and 40%. CONCLUSIONS: Our findings consolidate G-CSF as a drug that both reduces infarct size and enhances functional recovery. These effects are presumably dose dependent. In contrast to most other neuroprotectants, a beneficial outcome may also be achieved when treatment is delayed.
Jens Minnerup; Jan Heidrich; Jürgen Wellmann; Andreas Rogalewski; Armin Schneider; Wolf-Rüdiger Schäbitz
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2008-04-10
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-07-03     Revised Date:  2008-11-12    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1855-61     Citation Subset:  IM    
Universitätsklinikum Münster, Klinik und Poliklinik für Neurologie, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.
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MeSH Terms
Brain / blood supply,  drug effects,  physiopathology
Brain Ischemia / drug therapy*
Cerebral Arteries / drug effects*,  metabolism,  physiopathology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Granulocyte Colony-Stimulating Factor / pharmacology*,  therapeutic use
Movement Disorders / drug therapy,  etiology,  physiopathology
Neurologic Examination
Predictive Value of Tests
Recovery of Function / drug effects,  physiology
Treatment Outcome
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor
Comment In:
Stroke. 2008 Nov;39(11):e182; author reply e183   [PMID:  18802202 ]

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