| Meta-analysis of clinical studies of the efficacy of plasma exchange in the treatment of chronic progressive multiple sclerosis. | |
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MedLine Citation:
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PMID: 8770707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the hypothesis that addition of therapeutic plasma exchange (TPEX) to an immunosuppressive drug regimen increases that regimen's efficacy to halt the progression of chronic progressive multiple sclerosis (CPMS). METHODS: The literature was searched for prospective controlled clinical trials evaluating the efficacy of TPEX in CPMS. Six studies were eligible for meta-analysis. Their results were combined, using Cochran's and Peto's methods. Three outcome measures were studied: 1) the change in Kurtzke's disability status scale (DSS) scores, 2) the relative odds of neurologic decline by 1 or more DSS grades, and 3) the relative odds of neurologic improvement by 1 or more DSS grades, in the treatment versus the comparison group of patients. Reported results of neurologic evaluations at 6, 12, 24, and 36 months of follow-up were analyzed separately. RESULTS: TPEX significantly (P < .05) reduced the proportion of patients who experienced neurologic decline (by 1 or more DSS grades) at 12 months of follow-up (relative odds of decline = 0.441, 95% confidence interval = 0.210-0.929). CONCLUSIONS: There is a need for further clinical research into the possibility of a beneficial effect of TPEX in patients with CPMS likely to experience neurologic decline over the ensuring 12 months. Targeting treatment to a particular subgroup of CPMS patients may be necessary for TPEX to prove effective. |
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Authors:
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E C Vamvakas; A A Pineda; B G Weinshenker |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 10 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 1995 |
Date Detail:
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Created Date: 1996-09-25 Completed Date: 1996-09-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Affiliation:
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Blood Transfusion Service, Massachusetts General Hospital, Boston 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Disease Progression Humans Multiple Sclerosis / pathology, therapy* Odds Ratio Plasma Exchange* Prospective Studies Randomized Controlled Trials as Topic Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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