| Meta-analysis of the association between preterm delivery and intelligence. | |
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MedLine Citation:
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PMID: 21393308 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: An increasing proportion of infants are born preterm, and their survival has improved. Therefore, their long-term sequelae are of increasing public health importance. METHODS: We conducted a systematic review covering a 30 year period (1980-2009). A random effects meta-analysis provided a pooled estimate of the difference in IQ score between individuals born preterm and term. Small-study bias was examined using a funnel plot and Egger's test, and meta-regression was used to investigate possible causes of heterogeneity. Cumulative meta-analysis was used to determine if the magnitude of the association had changed over time. RESULTS: The 27 eligible studies covered 7044 individuals; 3504 (50%) delivered preterm and 3540 (50%) at term. They provided 37 estimates of difference in IQ. All demonstrated a reduced IQ among those delivered preterm and all but four reached statistical significance. Overall, IQ score was 11.94 (95% CI: 10.47-13.42, P < 0.001) points lower among children born preterm. There was moderate heterogeneity (overall I(2) 74.2%, P < 0.001), but no significant small-study bias (P = 0.524). The association between preterm delivery and IQ did not change significantly over time. There was a statistically significant, linear association across the gestational age range (adjusted coefficient: -0.91, 95% CI: -1.64, -0.17, P = 0.018). CONCLUSIONS: There is a strong and consistent body of evidence suggesting an association between preterm delivery and reduced IQ, with evidence of a dose-response relationship with gestational age. |
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Authors:
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C O Kerr-Wilson; D F Mackay; G C S Smith; J P Pell |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-9 |
Journal Detail:
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Title: Journal of public health (Oxford, England) Volume: - ISSN: 1741-3850 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101188638 Medline TA: J Public Health (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Population Health Sciences, University of Glasgow, Glasgow G12 8RZ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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