| Meta-analysis of association between optineurin gene and primary open-angle glaucoma. | |
| | |
MedLine Citation:
|
PMID: 20671613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Glaucoma is the leading cause of irreversible blindness in the world. Recent evidence indicates genetic susceptibility plays a role in primary open-angle glaucoma (POAG). The authors systematically investigated the association between optineurin (OPTN) gene polymorphisms and POAG. MATERIAL/METHODS: A meta-analysis of 25 published genetic association case-control studies, which examined the relation between POAG and the M98K, T34T, and R545Q polymorphisms of the OPTN gene, was carried out. RESULTS: For the T34T polymorphism, overall, the heterogeneity between studies was significant (P=0.0009), and the allele A was not associated with the risk of POAG relative to allele G (odds ratio: 1.14 [95% CI, 0.93 to 1.40]). In Asians and adults, the dominant model for allele A produced significant results (odds ratios: 1.50 [1.23 to 1.82] and 1.45 [1.10 to 1.91], respectively). Asian subjects also showed significance under the allele contrast model; however, the recessive model produced no significant results. Regarding the M98K and R545Q polymorphisms, the overall analysis did not detect a statistically significant association (odds ratios for the allele contrast models: 1.16 [0.96 to 1.40] and 1.14 [0.93 to 1.40], respectively). CONCLUSIONS: There is evidence of a modest positive association only between T34T polymorphism and POAG in Asians and adults. The M98K and R545Q polymorphisms have no association with POAG susceptibility. However, this meta-analysis exploring combinations of the polymorphisms may help us better understand the genetics of POAG. |
| | |
Authors:
|
Jin-Wei Cheng; Ping Li; Rui-Li Wei |
Related Documents
:
|
19672953 - Generation of an omgp allelic series in mice. 11094113 - Phenotype-genotype correlations in a cmt2b family with refined 3q13-q22 locus. 17320453 - Two deoxyribonuclease i gene polymorphisms and correlation between genotype and its act... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-30 Completed Date: 2010-11-03 Revised Date: 2011-06-14 |
Medline Journal Info:
|
Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
|
Languages: eng Pagination: CR369-77 Citation Subset: IM |
Affiliation:
|
Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Amino Acid Substitution / genetics Bias (Epidemiology) Genetic Association Studies* Glaucoma, Open-Angle / genetics* Humans Middle Aged Models, Genetic Odds Ratio Polymorphism, Single Nucleotide / genetics Transcription Factor TFIIIA / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/OPTN protein, human; 0/Transcription Factor TFIIIA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preoperative prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in patien...
Next Document: Attenuated lactate response to ischemic exercise in migraine.