Document Detail

Meta-analysis of amyloid-cognition relations in cognitively normal older adults.
MedLine Citation:
PMID:  23547267     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We conducted a meta-analysis of relationships between amyloid burden and cognition in cognitively normal, older adult humans.
METHODS: Methods of assessing amyloid burden included were CSF or plasma assays, histopathology, and PET ligands. Cognitive domains examined were episodic memory, executive function, working memory, processing speed, visuospatial function, semantic memory, and global cognition. Sixty-four studies representing 7,140 subjects met selection criteria, with 3,495 subjects from 34 studies representing independent cohorts. Weighted effect sizes were obtained for each study. Primary analyses were conducted limiting to independent cohort studies using only the most common assessment method (Pittsburgh compound B). Exploratory analyses included all assessment methods.
RESULTS: Episodic memory (r = 0.12) had a significant relationship to amyloid burden. Executive function and global cognition did not have significant relationships to amyloid in the primary analysis of Pittsburgh compound B (r = 0.05 and r = 0.08, respectively), but did when including all assessment methods (r = 0.08 and r = 0.09, respectively). The domains of working memory, processing speed, visuospatial function, and semantic memory did not have significant relationships to amyloid. Differences in the method of amyloid assessment, study design (longitudinal vs cross-sectional), or inclusion of control variables (age, etc.) had little influence.
CONCLUSIONS: Based on this meta-analytic survey of the literature, increased amyloid burden has small but nontrivial associations with specific domains of cognitive performance in individuals who are currently cognitively normal. These associations may be useful for identifying preclinical Alzheimer disease or developing clinical outcome measures.
Trey Hedden; Hwamee Oh; Alayna P Younger; Tanu A Patel
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-02     Completed Date:  2013-05-23     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-8     Citation Subset:  AIM; IM    
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MeSH Terms
Aging* / blood,  cerebrospinal fluid,  physiology
Amyloid beta-Peptides / metabolism*
Benzothiazoles / diagnostic use
Cognition / physiology*
Cognition Disorders* / blood,  cerebrospinal fluid,  radionuclide imaging
Cohort Studies
Cross-Sectional Studies
Neuropsychological Tests
Peptide Fragments / metabolism*
Positron-Emission Tomography
Grant Support
K01 AG040197/AG/NIA NIH HHS; K01 AG040197/AG/NIA NIH HHS; P01 AG036694/AG/NIA NIH HHS; P01 AG036694/AG/NIA NIH HHS; P41 RR14075/RR/NCRR NIH HHS; R01 AG034556/AG/NIA NIH HHS; R01 AG034570/AG/NIA NIH HHS
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Benzothiazoles; 0/N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole; 0/Peptide Fragments; 0/amyloid beta-protein (1-40); 0/amyloid beta-protein (1-42)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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