Document Detail

Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition.
MedLine Citation:
PMID:  22641753     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Infant formula is supplemented with long-chain polyunsaturated fatty acids (LCPUFAs) because they are hypothesized to improve cognition. Several randomized controlled clinical trials have examined the effect of LCPUFA supplementation of infant formula on cognitive development. We conducted this meta-analysis to examine the efficacy of LCPUFA supplementation of infant formula on early cognitive development.
METHODS: Two authors searched PubMed, PsychInfo, and Scopus for randomized controlled clinical trials assessing the efficacy of LCPUFA supplementation of infant formulas on cognition. Our analysis was restricted to randomized controlled clinical trials that examined the effect of LCPUFA supplementation on infant cognition using Bayley Scales of Infant Development. Our primary outcome was the weighted mean difference in Bayley Scales of Infant Development score between infants fed formula supplemented with LCPUFA compared with unsupplemented formula. We conducted secondary subgroup analyses and meta-regression to examine the effects of study sample, LCPUFA dose, and trial methodologic quality on measured efficacy of supplementation.
RESULTS: Twelve trials involving 1802 infants met our inclusion criteria. Our meta-analysis demonstrated no significant effect of LCPUFA supplementation of formula on infant cognition. There was no significant heterogeneity or publication bias between trials. Secondary analysis failed to show any significant effect of LCPUFA dosing or prematurity status on supplementation efficacy.
CONCLUSIONS: LCPUFA supplementation of infant formulas failed to show any significant effect on improving early infant cognition. Further research is needed to determine if LCPUFA supplementation of infant formula has benefits for later cognitive development or other measures of neurodevelopment.
Ahmad Qawasmi; Angeli Landeros-Weisenberger; James F Leckman; Michael H Bloch
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-28
Journal Detail:
Title:  Pediatrics     Volume:  129     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-08-07     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1141-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cognition / drug effects*,  physiology
Dietary Supplements*
Fatty Acids, Unsaturated / administration & dosage*
Infant Behavior / drug effects,  physiology,  psychology
Infant Formula / administration & dosage*
Randomized Controlled Trials as Topic / methods
Grant Support
1K23MH091240-01/MH/NIMH NIH HHS; K23 MH091240/MH/NIMH NIH HHS; R25 MH077823/MH/NIMH NIH HHS; R25 MH077823/MH/NIMH NIH HHS; T32 MH018268/MH/NIMH NIH HHS; T32MH018268-26/MH/NIMH NIH HHS; UL1 RR024139/RR/NCRR NIH HHS
Reg. No./Substance:
0/Fatty Acids, Unsaturated
Comment In:
Pediatrics. 2012 Jun;129(6):1166-7   [PMID:  22641756 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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