| Meta-analysis: excess mortality after hip fracture among older women and men. | |
| | |
MedLine Citation:
|
PMID: 20231569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although an increased risk for death after hip fracture is well established, whether this excess mortality persists over time is unclear. PURPOSE: To determine the magnitude and duration of excess mortality after hip fracture in older men and women. DATA SOURCES: Electronic search of MEDLINE and EMBASE for English and non-English articles from 1957 to May 2009 and manual search of article references. STUDY SELECTION: Prospective cohort studies were selected by 2 independent reviewers. The studies had to assess mortality in women (22 cohorts) or men (17 cohorts) aged 50 years or older with hip fracture, carry out a life-table analysis, and display the survival curves of the hip fracture group and age- and sex-matched control groups. DATA EXTRACTION: Survival curve data and items relevant to study validity and generalizability were independently extracted by 2 reviewers. DATA SYNTHESIS: Time-to-event meta-analyses showed that the relative hazard for all-cause mortality in the first 3 months after hip fracture was 5.75 (95% CI, 4.94 to 6.67) in women and 7.95 (CI, 6.13 to 10.30) in men. Relative hazards decreased substantially over time but did not return to rates seen in age- and sex-matched control groups. Through use of life-table methods, investigators estimated that white women having a hip fracture at age 80 years have excess annual mortality compared with white women of the same age without a fracture of 8%, 11%, 18%, and 22% at 1, 2, 5, and 10 years after injury, respectively. Men with a hip fracture at age 80 years have excess annual mortality of 18%, 22%, 26%, and 20% at 1, 2, 5, and 10 years after injury, respectively. LIMITATIONS: Cohort studies varied, sometimes markedly, in size, duration of observation, selection of control populations, ascertainment of death, and adjustment for comorbid conditions. Only published data that displayed findings with survival curves were examined. Publication bias was possible. CONCLUSION: Older adults have a 5- to 8-fold increased risk for all-cause mortality during the first 3 months after hip fracture. Excess annual mortality persists over time for both women and men, but at any given age, excess annual mortality after hip fracture is higher in men than in women. PRIMARY FUNDING SOURCE: Fund for Scientific Research and Willy Gepts Foundation, Universitair Ziekenhuis Brussel. |
| | |
Authors:
|
Patrick Haentjens; Jay Magaziner; Cathleen S Colón-Emeric; Dirk Vanderschueren; Koen Milisen; Brigitte Velkeniers; Steven Boonen |
Related Documents
:
|
1407239 - Mortality and causes of death after hip fractures in the netherlands. 15354899 - Risk indicators for posterior tooth fracture. 1541619 - Protein depletion and metabolic stress in elderly patients who have a fracture of the hip. 19002369 - Ten-year fracture probability identifies women who will benefit from clodronate therapy... 8162459 - Bone fractures in liver transplant patients. 15984419 - Epidemiology of hip fracture in japan: incidence and risk factors. 8279219 - Possible variation in bone resorption during the normal menstrual cycle. 4030449 - Periosteal transection and stripping for treatment of angular limb deformities in foals... 11675559 - Anterior femoral stapling. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of internal medicine Volume: 152 ISSN: 1539-3704 ISO Abbreviation: Ann. Intern. Med. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-16 Completed Date: 2010-04-15 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: United States |
Other Details:
|
Languages: eng Pagination: 380-90 Citation Subset: AIM; IM |
Affiliation:
|
Centre for Outcomes Research and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Jette, Vrije Universiteit Brussel, Elsene, Belgium. patrick.haentjens@uzbrussel.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Aged, 80 and over Cause of Death Female Hip Fractures / mortality* Humans Life Tables Male Risk Factors Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
|
K23 AG024787/AG/NIA NIH HHS; K23 AG024787-05/AG/NIA NIH HHS; P60 AG012583-10/AG/NIA NIH HHS; P60 AG12583/AG/NIA NIH HHS; R01 AG06322/AG/NIA NIH HHS; R01 HD0073/HD/NICHD NIH HHS; R37 AG009901-13/AG/NIA NIH HHS; R37 AG09901/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meta-analysis: Effects of Percutaneous Coronary Intervention Versus Medical Therapy on Angina Relief...
Next Document: Concierge Medicine: A "Regular" Physician's Perspective.