Document Detail

Meta-analysis of dysphagia and aspiration pneumonia in frail elders.
MedLine Citation:
PMID:  21940518     Owner:  NLM     Status:  MEDLINE    
As part of a systematic literature review, a comprehensive literature search was carried out to identify risk factors for aspiration pneumonia in frail older people. A prominent risk factor found was dysphagia with evidence level 2a, according to the Oxford Centre for Evidence-based Medicine Levels of Evidence. Subsequently, a meta-analysis of 4 cohort, 1 case-cohort, and 1 case-control study on dysphagia as a risk factor of aspiration pneumonia in frail older people was performed. Using a random effects model, we found a positive correlation between dysphagia and aspiration pneumonia: OR = 9.84; 95%CI = 4.15 - 23.33 (test for statistical homogeneity: p < 0.001). Then, a subgroup meta-analysis was performed with 4 cohort studies, all including patients with a cerebrovascular disease. Once again, a positive correlation was found between dysphagia and aspiration pneumonia: OR = 12.93; 95%CI = 8.61 - 19.44. The test for statistical homogeneity revealed no statistically significant result (p = 0.15). It was concluded that dysphagia is a serious risk factor for aspiration pneumonia in frail older people, particularly in those suffering from a cerebrovascular disease.
C D van der Maarel-Wierink; J N O Vanobbergen; E M Bronkhorst; J M G A Schols; C de Baat
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2011-09-22
Journal Detail:
Title:  Journal of dental research     Volume:  90     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-01-10     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1398-404     Citation Subset:  D; IM    
BENECOMO, Flemish-Netherlands Geriatric Oral Research Group, The Netherlands.
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MeSH Terms
Aged, 80 and over
Deglutition Disorders / complications*
Frail Elderly*
Middle Aged
Odds Ratio
Pneumonia, Aspiration / etiology*
Proportional Hazards Models
Risk Factors
Statistics, Nonparametric
Comment In:
J Evid Based Dent Pract. 2012 Dec;12(4):199-200   [PMID:  23177497 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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