| A Meta-analysis of 64-section Coronary CT Angiography Findings for Predicting 30-day Major Adverse Cardiac Events in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome. | |
| | |
MedLine Citation:
|
PMID: 22055795 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: To determine the accuracy of 64-section coronary computed tomography angiography (CCTA) in predicting 30 day major adverse cardiac events (MACE) for patients presenting with symptoms concerning for acute coronary syndrome (ACS). MATERIALS AND METHODS: Electronic databases between January 1, 2005, and May, 1, 2011, and reference lists from relevant published research articles were searched. We included studies on adult patients who presented with active symptoms suggestive of ACS, had immediate 64-section CCTA performed and were assessed for MACE at a minimum of 30 days past their initial presentation. Studies had to report or provide sufficient detail to determine sensitivity, specificity, positive predictive value, and negative predictive value in relation to MACE using a 50% diameter stenosis as cutoff criterion for coronary artery disease. RESULTS: Nine studies were included for a total of 1559 patients studied (42.3% women, mean age 51.9 ± 10.6). Patients ranged from low to intermediate risk for ACS. All had initial inconclusive electrocardiograms and negative cardiac biomarker results. A total of 14.8% of patients had a positive CCTA result. The pooled sensitivity was 93.3% (95% CI 88.3%-96.6%), specificity was 89.9% (95% CI 88.3%-91.3%), positive predictive value was 48.1% (95% CI 42.5%-53.8%), and negative predictive value was 99.3% (95% CI 98.7%-99.6%). CONCLUSION: Sixty-four section CCTA had a 99.3% negative predictive value in excluding MACE for 30 days after initial symptom presentation in 85.2% of our study population. Although the value of 64-section CCTA is best for identifying patients who can safely be discharged home, it is less useful for patients who have positive results. |
| | |
Authors:
|
Kevin M Takakuwa; Scott W Keith; Adrian T Estepa; Frances S Shofer |
Related Documents
:
|
9676945 - Tc-99m hmpao leukocyte and tc-99m nanocolloid scintigraphy in posttraumatic bone infect... 2649775 - Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when comp... 19638845 - Simultaneous occurrence of partial anomalous pulmonary venous return and major bronchia... 6888695 - Twist drill craniostomy and closed system drainage of chronic and subacute subdural hem... 17602175 - Is co-morbidity taken into account in the antibiotic management of elderly patients wit... 20140825 - Diagnostic accuracy of esophageal capsule endoscopy versus conventional upper digestive... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Academic radiology Volume: 18 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1522-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Thomas Jefferson University Hospital, 111 S. 11th Street, Philadelphia, PA 19107. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fissures Segmentation Using Surface Features: Content-based Retrieval for Mammographic Mass Using En...
Next Document: Different Algorithms for Quantitative Analysis of Myocardial Infarction with DE MRI: Comparison with...