Document Detail

Meta-Analysis of Maternal and Neonatal Outcomes Associated with the Use of Insulin Glargine versus NPH Insulin during Pregnancy.
MedLine Citation:
PMID:  22685467     Owner:  NLM     Status:  PubMed-not-MEDLINE    
As glargine, an analog of human insulin, is increasingly used during pregnancy, a meta-analysis assessed its safety in this population. A systematic literature search identified studies of gestational or pregestational diabetes comparing use of insulin glargine with human NPH insulin, with at least 15 women in both arms. Data was extracted for maternal outcomes (weight at delivery, weight gain, 1st/3rd trimester HbA(1c), severe hypoglycemia, gestation/new-onset hypertension, preeclampsia, and cesarean section) and neonatal outcomes (congenital malformations, gestational age at delivery, birth weight, macrosomia, LGA, 5 minute Apgar score >7, NICU admissions, respiratory distress syndrome, neonatal hypoglycemia, and hyperbilirubinemia). Relative risk ratios and weighted mean differences were determined using a random effect model. Eight studies of women using glargine (331) or NPH (371) were analyzed. No significant differences in the efficacy and safety-related outcomes were found between glargine and NPH use during pregnancy.
Jacques Lepercq; Jay Lin; Gillian C Hall; Edward Wang; Marie-Paule Dain; Matthew C Riddle; Philip D Home
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Publication Detail:
Type:  Journal Article     Date:  2012-05-16
Journal Detail:
Title:  Obstetrics and gynecology international     Volume:  2012     ISSN:  1687-9597     ISO Abbreviation:  Obstet Gynecol Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-08-23     Revised Date:  2013-02-27    
Medline Journal Info:
Nlm Unique ID:  101517078     Medline TA:  Obstet Gynecol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649070     Citation Subset:  -    
Service de Gynécologie-Obstétrique, Hôpital Cochin-Saint Vincent de Paul, Cedex 14, 75674 Paris, France.
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