| A meta-analysis evaluating the impact of chitosan on serum lipids in hypercholesterolemic patients. | |
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MedLine Citation:
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PMID: 19923803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVE: Chitosan is increasingly being used in the United States as an over-the-counter cholesterol-lowering agent. The positively charged amino groups of chitosan may have the ability to bind negatively charged molecules such as lipids and bile acids, inducing a greater fractional excretion in the feces. To better characterize the impact of chitosan on serum lipids in hypercholesterolemic patients, we performed a meta-analysis of randomized controlled trials. METHODS: A systematic literature search of Medline, Embase, Cochrane Central and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through May 2008. Trials were included in the analysis if they were randomized, placebo-controlled trials of chitosan in hypercholesterolemic patients and reported efficacy data on total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol or triglycerides. The weighted mean difference (WMD) of the change from baseline (in milligrams per deciliter) with 95% confidence interval was calculated as the difference between the mean in the chitosan and placebo groups using a random-effects model. RESULTS: Six studies (n = 416 patients) met the inclusion criteria. Upon meta-analysis, the use of chitosan significantly lowered total cholesterol [WMD, -11.59 mg/dl (-21.45 to -1.73), p = 0.02] but not LDL cholesterol, HDL cholesterol or triglycerides. CONCLUSIONS: Based upon the currently available literature, we can only say that chitosan beneficially affects total cholesterol with 95% confidence. Additional, larger randomized controlled trials are needed to better characterize the effect of chitosan on other lipoproteins. |
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Authors:
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William L Baker; Alix Tercius; Moise Anglade; C Michael White; Craig I Coleman |
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Publication Detail:
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Type: Journal Article; Meta-Analysis Date: 2009-11-13 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 55 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 368-74 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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University of Connecticut School of Pharmacy, Storrs, CT, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Chitosan / therapeutic use* Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Dietary Supplements* Humans Hypercholesterolemia / therapy* Randomized Controlled Trials as Topic Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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