Document Detail

Measurement of the membrane elasticity of red blood cell with osmotic pressure by optical tweezers.
MedLine Citation:
PMID:  19448857     Owner:  NLM     Status:  MEDLINE    
Cells have to undergo many changes in osmotic pressure during their long-term preservation, and will have injuries before they return to their normal states. Mechanics of a cell with deformation, either small or large, is usually used to describe the change of the cell quantitatively. However, there are few reports on the deformation of cells subjected to the change of osmotic pressures during preservation. Here, we report our study of the elasticity of the human red blood cells under osmotic pressures using optical tweezers. We find that the deformation characteristics of erythrocytes are strongly dependent on the osmotic pressure. We also find the RBCs will become stiff with increasing osmotic pressure, suggesting a potential reason for membrane injury during preservation.
Jianguang Wu; Yinmei Li; Di Lu; Zhong Liu; Zhengdong Cheng; Liqun He
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cryo letters     Volume:  30     ISSN:  0143-2044     ISO Abbreviation:  Cryo Letters     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9891832     Medline TA:  Cryo Letters     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Department of Physics, University of Science and Technology of China, National Laboratory for Physical Sciences at Microscale, Hefei, China.
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MeSH Terms
Erythrocyte Deformability*
Erythrocyte Membrane / chemistry*
Hypertonic Solutions / chemistry
Hypotonic Solutions / chemistry
Optical Tweezers*
Osmotic Pressure
Reg. No./Substance:
0/Hypertonic Solutions; 0/Hypotonic Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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