| Mesopic foveal contrast sensitivity is impaired in diabetic patients without retinopathy. | |
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MedLine Citation:
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PMID: 20499079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Contrast sensitivity (CS) has been studied extensively to determine its effectiveness as a test for diagnosing early and advanced diabetic retinopathy. Various techniques have been adopted to measure CS, and most of them reported a significant difference between diabetic and normal eyes. Our purpose is to demonstrate differences in foveal CS between diabetic patients without retinopathy and healthy subjects under mesopic and photopic conditions, using a simple, rapid computerized test. METHODS: Seventeen eyes of nine patients with type 2 diabetes without diabetic retinopathy were included. Fourteen eyes of seven non-diabetic patients served as controls. All the patients underwent a careful ophthalmologic examination, including ETDRS chart visual acuity, color photographs, and optical coherence tomography (OCT). Patients with any ocular disease were excluded. All eyes had a visual acuity of 20/25 or better, a normal eye examination and optical coherence tomography (OCT). Photopic and mesopic contrast sensitivity was tested using a computerized psychophysical static method involving four forced-choice procedures. The targets were Gabor patches with spatial frequencies of 3-12 cycles per degree (cpd). The mesopic testing was conducted in a completely darkened room; the monitor was covered with a neutral density filter, allowing luminance of only 0.9 cd/m(2). RESULTS: The average age was similar: 59.1 ± 5.3 years in the diabetic group vs 61.4 ± 3.2 years in the control group. The average duration of diabetes was 16 years (range 6-26). The average visual acuity was 0.04 ± 0.01 logMAR and 0.01 ± 0.01 logMAR in the diabetic and control groups respectively. Photopic foveal CS was similar in both groups. Significantly lower CS was found in diabetic patients under mesopic conditions at a spatial frequency of 3 (p < 0.008). At higher spatial frequencies, the mesopic contrast sensitivity was very low in both groups and without a significant difference. CONCLUSIONS: Mesopic foveal CS is impaired in diabetic patients despite good visual acuity, a normal fundus examination and normal OCT. Early central visual function impairment may occur in diabetic patients before the appearance of retinopathy. |
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Authors:
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Gabriel Katz; Hani Levkovitch-Verbin; Giora Treister; Michael Belkin; Jacob Ilany; Uri Polat |
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Publication Detail:
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Type: Journal Article Date: 2010-05-25 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 248 ISSN: 1435-702X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
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Languages: eng Pagination: 1699-703 Citation Subset: IM |
Affiliation:
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Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Tel-Aviv University, 52621, Tel-Aviv, Israel. gabrielkatz.dr@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Contrast Sensitivity / physiology* Diabetes Mellitus, Type 2 / physiopathology* Diabetic Retinopathy / physiopathology Female Fovea Centralis / physiology* Humans Male Mesopic Vision / physiology* Middle Aged Vision Disorders / physiopathology* |
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