Document Detail

Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study.
MedLine Citation:
PMID:  8848454     Owner:  NLM     Status:  MEDLINE    
The mesolimbic dopaminergic system (MDS) has been shown to be implicated in feeding behaviors. The present experiment was conducted to examine the effects of the sensory properties of food ingested on MDS activity. Microdialysis coupled to high-performance liquid chromatography with electrochemical detection was employed to measure the extracellular levels of dopamine (DA) and its main metabolites (DOPAC and HVA) in the nucleus accumbens of freely moving rats. During microdialysis sessions rats had access or not to powdered foods varying in palatability: short cakes as highly palatable (HP) food and regular chow as low palatable (LP) food. In the absence of food, there were no alterations in extracellular levels of DA, DOPAC, and HVA. During feeding, DA rose significantly with a greater rise for the HP than the LP food. Levels of DOPAC and HVA only reached significance with the HP food. The results indicate that the MDS is activated on ingestion of food, and suggest that MDS activity is related to the rewarding properties of foods.
P Martel; M Fantino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  53     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Dopamine / metabolism,  physiology*
Homovanillic Acid / metabolism
Limbic System / anatomy & histology,  metabolism,  physiology*
Nucleus Accumbens / anatomy & histology,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; VTD58H1Z2X/Dopamine; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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