| Mesolimbic dopamine neurotransmission is increased by administration of mu-opioid receptor antagonists. | |
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MedLine Citation:
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PMID: 7902813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microdialysis and high pressure liquid chromatography were used to assess the effects of ventral tegmental area microinjections of the mu-opioid receptor antagonists D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) and beta-funaltrexamine (beta-FNA) on extracellular ventral striatal dopamine and metabolite concentrations. While CTOP is known to antagonize the increases in extracellular ventral striatal dopamine and dopamine metabolite concentrations induced by ventral tegmental area microinjections of a mu-opioid receptor agonist, it produced dose-orderly increases in ventral striatal dopamine and dopamine metabolite concentrations when administered by itself. beta-FNA also elevated dopamine and metabolite concentrations. These mu-agonist-like effects of the mu-opioid receptor antagonists were unexpected and suggest that a complex local circuitry mediates opioid-dopamine interactions in the ventral tegmental area. Since mu-opioids are known to act on ventral tegmental neurons that contain gamma-aminobutyric acid (GABA), a model of interactions between GABAergic afferents to the ventral tegmental area and ventral tegmental GABAergic interneurons is proposed. |
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Authors:
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D P Devine; P Leone; R A Wise |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 243 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-12 Completed Date: 1994-01-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 55-64 Citation Subset: IM |
Affiliation:
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Department of Psychology, Concordia University, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Dopamine / analysis, physiology* Injections, Intraventricular Male Microdialysis Molecular Sequence Data Naltrexone / administration & dosage, analogs & derivatives, pharmacology Narcotic Antagonists / administration & dosage, pharmacology Nucleus Accumbens / chemistry, drug effects* Rats Rats, Inbred Strains Receptors, Opioid, mu / antagonists & inhibitors* Somatostatin / administration & dosage, analogs & derivatives*, pharmacology Ventral Tegmental Area / chemistry, drug effects* gamma-Aminobutyric Acid / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA 01720/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 0/Receptors, Opioid, mu; 103429-31-8/phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide; 16590-41-3/Naltrexone; 51110-01-1/Somatostatin; 56-12-2/gamma-Aminobutyric Acid; 72782-05-9/beta-funaltrexamine |
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