Document Detail

Mesoglia & microglia--a historical review of the concept of mononuclear phagocytes within the central nervous system.
MedLine Citation:
PMID:  12557654     Owner:  NLM     Status:  MEDLINE    
More than a century and a half has elapsed since the first accounts of mesodermal phagocytic elements were proposed within the central nervous system. Over the intervening decades, body and substance were added to this concept through the advancement of histological techniques at the disposal of the researcher and the acute and keen-minded skills of the pathologist. Notable among these pioneering efforts were the contributions of W. Ford Robertson, Santiago Ramon y Cajal, Pio del Rio-Hortega and Wilder Penfield amongst an entire cavalcade of other noteworthy figures. The term 'mesoglia' and 'third element of the nervous system' was bestowed upon these cells towards the beginning of the twentieth century to account for their separate origins from neurons and macroglia. It was later amended by del Rio-Hortega in 1919, to 'microglia' in order to further discriminate between true mesodermal elements and oligodendrocytes, previously regarded as a component of 'mesoglia'. This particular contention sparked much controversy among del Rio-Hortega's peers and resulted in an escalation of fruitful research throughout Europe that eventually declined up to the outbreak of the Second World War. The post-war years were a period of the 'dark ages' that cast doubt on the very existence and nature of microglia, until the 'renaissance' of research was once again rejuvenated in the 1960s, by a new cohort of intrigued minds: Cammermeyer, Blinzinger, Kreutzberg and others who saw in the 'third element' the potential that is now commonly ascribed to microglia: the intrinsic immune effector cells of the CNS. It is now universally accepted that microglia are involved as the first line of rapid defence in any pathology of the nervous system, and as such, present a diagnostic tool for the neuropathologist. Although our knowledge of microglia stems from an extensive body of work conducted over the last two decades, much of the earlier work (pre-1960s) has remained somewhat obscure. This is partly accountable due to the limited availability of translated works, and additionally to the lack of a compendium of these articles. This paper will present a comprehensive overview of the pioneering research on mononuclear phagocytes within the central nervous system, which has direct bearing on our present-day understanding of the concept of microglia.
Payam Rezaie; David Male
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Journal of the history of the neurosciences     Volume:  11     ISSN:  0964-704X     ISO Abbreviation:  J Hist Neurosci     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9441330     Medline TA:  J Hist Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  325-74     Citation Subset:  IM; Q    
Department of Neuropathology, Institute of Psychiatry, SE5 8AF, UK.
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MeSH Terms
Central Nervous System / immunology*
Ectoderm / immunology
History, 19th Century
History, 20th Century
Mesoderm / immunology*
Microglia / immunology*
Monocytes / immunology*
Neuroglia / immunology*
Neurosciences / history
Phagocytosis / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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