Document Detail


Mesenteric vein thrombosis and vascular plasminogen activator.
MedLine Citation:
PMID:  6688517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 60-year-old woman with livedo reticularis was examined for defective release of vascular plasminogen activator by a newly described chromogenic assay. Her activator level was only 0.007 Committee on Thrombolytic Agents (CTA) units/mL, compared with a mean of 0.19 CTA units/mL for 84 female controls. Subsequently, the patient died as a result of thrombosis of the portal, splenic, hepatic and superior mesenteric veins with small-bowel infarction. The patient's family had a history of deep and superficial vein thrombosis. Her family's medical history was similar to a recently described pedigree, with low levels of releasable plasminogen activator associated with venous thrombosis. We believe that mesenteric vein thrombosis is a serious potential consequence of defective release of vascular plasminogen activator.
Authors:
O B Boyko; S V Pizzo
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  107     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-2     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Mesenteric Veins* / metabolism
Middle Aged
Pedigree
Plasminogen Activators / analysis,  metabolism*
Thrombosis / genetics,  metabolism*,  mortality
Grant Support
ID/Acronym/Agency:
HL 24066/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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