| Mesenteric lymph node stroma cells in the generation of intestinal immune responses. | |
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MedLine Citation:
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PMID: 19649572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymph nodes at different anatomical locations share similar architecture and operate on the basis of identical principles. Still, the quality of immune responses is modified substantially by the local peculiarities at the site of its induction. Here, we discuss how lymph node stroma cells contribute to functional differences between various lymph nodes, thus helping to explain why and how an immune response induced in skin draining peripheral lymph nodes differs from that elicited in the gut draining mesenteric lymph nodes. Stroma cells constitute a major part of the lymph node scaffold and control the flow of immune cells as well as soluble substances within the organ. Moreover, stroma cells express cytokines, chemokines as well as adhesion factors and thereby actively influence immune status. Lymph node transplantations and adoptive transfers of dendritic cells demonstrated that regional lymph node stroma cells differ in their ability to support mucosal tolerance, the induction of tissue tropism, and humoral immunity. This suggests that stroma cells shape tissue-specific immune responses and equip lymph nodes with unique functional properties that might originate during lymph node organogenesis. |
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Authors:
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Oliver Pabst; Benjamin Wahl; Günter Bernhardt; Swantje I Hammerschmidt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-08-01 |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: 87 ISSN: 1432-1440 ISO Abbreviation: J. Mol. Med. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-06 Completed Date: 2009-12-04 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 945-51 Citation Subset: IM |
Affiliation:
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Institute of Immunology, Hannover Medical School, Hannover, Germany. Pabst.Oliver@MH-Hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epithelial Cells / immunology Immune System / physiology* Intestines / immunology* Lymph Nodes* / cytology, immunology Mesentery* / anatomy & histology, immunology Signal Transduction / physiology Stromal Cells / cytology, immunology* Tretinoin / metabolism |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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