| Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis. | |
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MedLine Citation:
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PMID: 16226961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Both experimental and clinical studies have shown that acute pancreatitis (AP) causes a significant decrease in red blood cell (RBC) deformability. The mechanisms by which AP induces RBC injury are unknown. The purpose of this study was to test the hypothesis that factors carried in the mesenteric lymph after an attack of AP significantly contribute to the RBC injury observed in AP. METHODS: RBC deformability was determined by means of laser-assisted ektacytometry in mesenteric lymph duct-ligated and non-ligated rats subjected to AP and in sham-operated animals. RESULTS: AP was associated with significant alterations of RBC deformability indices, namely the elongation index and half maximal RBC elongation. Pancreatitis-induced RBC deformability changes were partially prevented by mesenteric lymph duct ligation. CONCLUSIONS: Mesenteric lymph in AP contains factors that cause RBC damage, which is manifested by decreased deformability. Interruption of the lymph flow from the injured gut into the bloodstream decreases these RBC alterations. |
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Authors:
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Tamara L Berezina; Sergey B Zaets; Damian J Mole; Zoltan Spolarics; Edwin A Deitch; George W Machiedo |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of surgery Volume: 190 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-17 Completed Date: 2005-11-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 800-4 Citation Subset: AIM; IM |
Affiliation:
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University of Medicine and Dentistry of New Jersey-New Jersey Medical School, MSB, Room G-507, 185 S. Orange Ave., Newark, NJ 07103, USA. tberezina@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Size* Disease Models, Animal Erythrocyte Deformability* Erythrocytes / pathology* Laser Scanning Cytometry Ligation Lymphatic Vessels / surgery* Male Mesentery* Multiple Organ Failure / blood, etiology, prevention & control Pancreatitis, Acute Necrotizing / blood*, complications Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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GM59841/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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