| Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes. | |
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MedLine Citation:
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PMID: 22278737 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Diabetes is a risk factor for perioperative complications after cardiac surgery. We studied its effects on mesenteric endothelial function in a cardiopulmonary bypass (CPB) model.Methods: Forty Wistar rats were divided into four groups: sham (D-CPB-), cardiopulmonary bypass (D-CPB+), diabetic (D+CPB-) and diabetic that have undergone CPB (D+CPB+). Two samples of mesenteric artery were used for nitric oxide synthase (NOS) Western blot analysis, and two others for assessing contractile response and endothelium relaxations. Nitrite products and tumour necrosis factor-alpha (TNF-α) were assessed as markers of inflammatory response.Results: We observed an enhanced contractile response to the α-adrenergic agonist associated with impairment of mesenteric vasorelaxation in D+CPB+ rats. Western immunoblot analysis of D+CPB+ highlighted an additive effect of hyper-expression of inducible NOS. A significantly increased inflammatory response was observed after CPB in diabetic animals.Conclusions: This work confirms the potential deleterious impact of diabetes on the mesenteric endothelium during CPB in cardiac surgery. |
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Authors:
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Vincent Le Guillou; Fabienne Tamion; Isabelle Jouet; Vincent Richard; Paul Mulder; Jean Paul Bessou; Fabien Doguet |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease Volume: - ISSN: 1752-8984 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234011 Medline TA: Diab Vasc Dis Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Rouen University Hospital, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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