Document Detail

Mesenchyme to epithelium transition during development of the mammalian kidney tubule.
MedLine Citation:
PMID:  9124036     Owner:  NLM     Status:  MEDLINE    
Kidney epithelia have two separate origins. Collecting ducts develop in the manner of most glandular organs, by growth and branching of a bud derived from a pre-existing epithelium. Excretory tubules develop by a direct mesenchyme to epithelium transition (MET), which is induced by the tips of the developing collecting duct system as it invades a specialised area of mesenchymal cells. The process by which these metanephrogenic mesenchyme cells achieve MET can be divided into several stages; induction, acquisition of stem cell character, fate determination, condensation, epitheliogenesis, polarisation and maturation. Progress through these stages is regulated by 'checkpoints' at which permission to proceed requires specific signals. The stages of development are characterised by the expression of new combinations of genes that code for transcription factors (Hox genes, Pax genes, zinc finger proteins), signalling effectors (growth factors, Wnts, receptor tyrosine kinases) and morphoregulatory molecules (CAMs, cadherins, extracellular matrix ligands). This review summarises current knowledge about the molecular interactions that control MET in the kidney, and also about how their failure might result in Wilms' tumour, one of the most common cancers of childhood.
J A Davies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta anatomica     Volume:  156     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  187-201     Citation Subset:  IM    
Department of Anatomy, Edinburgh University Medical School, UK.
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MeSH Terms
Embryonic Induction
Epithelial Cells
Epithelium / physiology
Kidney / embryology
Kidney Glomerulus / embryology
Kidney Tubules / embryology*
Mesoderm / physiology*
Stem Cells
Wilms Tumor / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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