| Mesenchyme cells can function to induce epithelial cell proliferation in starfish embryos. | |
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MedLine Citation:
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PMID: 20063413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here, we show that mesenchyme cells have a novel morphogenetic function in epithelial cell proliferation in starfish embryos. Blastula embryos were injected with pure populations of mesenchyme cells and the total cell numbers in the treated embryos were subsequently determined at different developmental stages. When a total of 40-50 mesenchyme cells was injected, total cells numbers in mid-gastrula embryos and 3-day-old bipinnaria larvae increased significantly (by 1.3-fold) compared with controls, with no indication of any mitotic activity in the injected mesenchyme cells. However, injection of more than 150 mesenchyme cells failed to induce proliferation of the epithelial cells and, moreover, interfered with normal morphogenesis. These developmental abnormalities occurred concomitantly with a severe condensation of the fibrous component of the extracellular matrix. Our data suggest that epithelial cell proliferation is induced by an appropriate number of mesenchyme cells in concert with the fibrous component of the extracellular matrix. |
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Authors:
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Gen Hamanaka; Midori Matsumoto; Masaya Imoto; Hiroyuki Kaneko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 818-27 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Wiley-Liss, Inc. |
Affiliation:
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School of Fundamental Science and Technology, Department of Biology, Keio University, Kohoku-ku, Yokohama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastula / metabolism Bromodeoxyuridine / pharmacology Cell Proliferation Epithelial Cells / cytology* Extracellular Matrix / metabolism Flow Cytometry / methods Gastrula / metabolism Gene Expression Regulation, Developmental* Mesoderm / cytology* Mitosis Morphogenesis / physiology Starfish |
| Chemical | |
Reg. No./Substance:
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59-14-3/Bromodeoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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