Document Detail


Mesenchyme cells can function to induce epithelial cell proliferation in starfish embryos.
MedLine Citation:
PMID:  20063413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here, we show that mesenchyme cells have a novel morphogenetic function in epithelial cell proliferation in starfish embryos. Blastula embryos were injected with pure populations of mesenchyme cells and the total cell numbers in the treated embryos were subsequently determined at different developmental stages. When a total of 40-50 mesenchyme cells was injected, total cells numbers in mid-gastrula embryos and 3-day-old bipinnaria larvae increased significantly (by 1.3-fold) compared with controls, with no indication of any mitotic activity in the injected mesenchyme cells. However, injection of more than 150 mesenchyme cells failed to induce proliferation of the epithelial cells and, moreover, interfered with normal morphogenesis. These developmental abnormalities occurred concomitantly with a severe condensation of the fibrous component of the extracellular matrix. Our data suggest that epithelial cell proliferation is induced by an appropriate number of mesenchyme cells in concert with the fibrous component of the extracellular matrix.
Authors:
Gen Hamanaka; Midori Matsumoto; Masaya Imoto; Hiroyuki Kaneko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-27     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Wiley-Liss, Inc.
Affiliation:
School of Fundamental Science and Technology, Department of Biology, Keio University, Kohoku-ku, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastula / metabolism
Bromodeoxyuridine / pharmacology
Cell Proliferation
Epithelial Cells / cytology*
Extracellular Matrix / metabolism
Flow Cytometry / methods
Gastrula / metabolism
Gene Expression Regulation, Developmental*
Mesoderm / cytology*
Mitosis
Morphogenesis / physiology
Starfish
Chemical
Reg. No./Substance:
59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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