Document Detail

Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
MedLine Citation:
PMID:  23146942     Owner:  NLM     Status:  MEDLINE    
In recent years, mesenchymal stromal cells (MSCs) and regulatory T cells (Tregs) have both garnered significant interest from immunologists worldwide, not least because of the potential application of both cell types in the treatment of many chronic inflammatory and autoimmune diseases. Although both MSCs and Tregs can be considered immunosuppressive in their own right, the induction of Tregs by activated MSCs is now a well-publicised phenomenon; however, only recently have the mechanisms involved in this induction started to become clear. Indeed, it is becoming increasingly apparent that there exists a complex interplay between the two lineages leading to this potent inhibition of the host immune response. Cell contact, soluble mediators-including prostaglandin E(2) and transforming growth factor β-and indirect induction via manipulation of other antigen-presenting cells all appear to have vital roles in the interactions between MSCs and Tregs. Much still remains to be discovered before we have a full understanding of this important aspect of the immune response, but there have already been a multitude of clinical trials suggesting that MSC/Treg therapies could offer significant benefits in the treatment of both autoimmune disease and graft versus host disease. Although these therapies are still in their infancy, the synergy between MSCs and Tregs will undoubtedly yield future breakthroughs in the treatment of many debilitating conditions and usher in a new wave of targeted, cell-based therapeutics.
Stephen P Burr; Francesco Dazzi; Oliver A Garden
Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-13
Journal Detail:
Title:  Immunology and cell biology     Volume:  91     ISSN:  1440-1711     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-06-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  12-8     Citation Subset:  IM    
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MeSH Terms
Antigen-Presenting Cells / immunology
Autoimmune Diseases / immunology,  therapy
Cell- and Tissue-Based Therapy / methods
Dinoprostone / immunology
Graft vs Host Disease / immunology,  therapy
Immune Tolerance*
Mesenchymal Stromal Cells / immunology*
T-Lymphocytes, Regulatory / immunology*
Transforming Growth Factor beta / immunology
Grant Support
MC_G0802523//Medical Research Council
Reg. No./Substance:
0/Transforming Growth Factor beta; K7Q1JQR04M/Dinoprostone
Comment In:
Immunol Cell Biol. 2013 Jan;91(1):3-4   [PMID:  23295414 ]

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