Document Detail


Mesenchymal stromal cells: misconceptions and evolving concepts.
MedLine Citation:
PMID:  23321325     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nearly half a century has passed since the publication of the first articles describing plastic-adherent cells from bone marrow, referred to initially as colony-forming unit fibroblasts, then marrow stromal cells, mesenchymal stem cells and most recently multipotent mesenchymal stromal cells (MSCs). As expected, our understanding of the nature and biologic functions of MSCs has undergone major paradigm shifts over this time. Despite significant advances made in deciphering their complex biology and therapeutic potential in both experimental animal models and human clinical trials, numerous misconceptions regarding the nature and function of MSCs have persisted in the field. Continued propagation of these misconceptions in some cases may significantly impede the advancement of MSC-based therapies in clinical medicine. We have identified six prevalent misconceptions about MSCs that we believe affect the field, and we attempt to rectify them based on current available data.
Authors:
Donald G Phinney; Luc Sensebé
Related Documents :
23963825 - Downregulation of mir-15a due to lmp1 promotes cell proliferation and predicts poor pro...
23941115 - Utilization of trec and krec quantification for the monitoring of early t- and b-cell n...
19168675 - Notch mediates wnt and bmp signals in the early separation of smooth muscle progenitors...
24182705 - Monoclonal gammopathy-associated proliferative glomerulonephritis.
22062805 - In situ detection of hy-specific t cells in acute graft-versus-host disease-affected ma...
9789735 - Age-related changes in the absolute number of cd95 positive cells in t cell subsets in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytotherapy     Volume:  15     ISSN:  1477-2566     ISO Abbreviation:  Cytotherapy     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100895309     Medline TA:  Cytotherapy     Country:  England    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, USA. Electronic address: dphinney@scripps.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tum...
Next Document:  Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filte...