Document Detail

Mesenchymal stem cell therapy for injured growth plate .
MedLine Citation:
PMID:  23277086     Owner:  NLM     Status:  In-Data-Review    
The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included.
Awang B Shukrimi; Mohd H Afizah; Jacqueline F Schmitt; James Hp Hui
Related Documents :
23325836 - Delivery of viral vectored vaccines by b cells represents a novel strategy to accelerat...
23352646 - Mesenchymal and stem-like cell properties targeted in suppression of chronically-induce...
3517006 - Myosin types and fiber types in cardiac muscle. iii. nodal conduction tissue.
24329796 - Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell tr...
2530156 - Immobilized anti-cd3 monoclonal antibodies induce accessory cell-independent lymphokine...
25339956 - Cellular plasticity of cd4+ t cells in the intestine.
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-85     Citation Subset:  IM    
Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, Department of Orthopaedic Surgery, National University Health System, National University of Singapore, 1E, Kent Ridge Road, Singapore 119288.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases.
Next Document:  Biomolecular interactions: essential instrumentation methods .