Document Detail

Mesenchymal stem cell differentiation on microstructured poly (methyl methacrylate) substrates.
MedLine Citation:
PMID:  19008086     Owner:  NLM     Status:  MEDLINE    
Recent studies on 2D substrates have revealed the importance of surface properties in affecting cell behaviour. In particular, surface topography appears to influence and direct cell migration. The development of new technologies of hot embossing and micro-imprinting has made it possible to study cell interactions with controlled micro features and to determine how these features can affect cell behaviour. Several studies have been carried out on the effect of microstructures on cell adhesion, cell guidance and cell proliferation. However, there is still a lack of knowledge on how these features affect mesenchymal stem cell differentiation. This study was designed to evaluate whether highly controlled microstructures on PMMA could induce rMSC differentiation into an osteogenic lineage. Structured PMMA was seeded with rMSC and cell number; cell morphology and cell differentiation were evaluated. Results confirm that microstructures not only affect cell proliferation and alignment but also have a synergistic effect with osteogenic medium on rMSC differentiation into mature osteoblasts.
Elisabeth Engel; Elena Martínez; Chris A Mills; Miriam Funes; Josep A Planell; Josep Samitier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-27
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  191     ISSN:  1618-0402     ISO Abbreviation:  Ann. Anat.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  136-44     Citation Subset:  IM    
Bio/Non-Bio Interactions for Regenerative Medicine Group, Institute for Bioengineering of Catalonia (IBEC), Josep Samitier 1-5, 08028 Barcelona, Spain.
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MeSH Terms
Bone Marrow Cells / cytology
Cell Count
Cell Culture Techniques / methods
Cell Differentiation / physiology*
Cell Division
Culture Media
Mesenchymal Stem Cells / cytology*
Microtechnology / methods*
Polymethyl Methacrylate
Rats, Wistar
Surface Properties
Reg. No./Substance:
0/Culture Media; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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