| Mesenchymal stem cell differentiation on microstructured poly (methyl methacrylate) substrates. | |
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MedLine Citation:
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PMID: 19008086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies on 2D substrates have revealed the importance of surface properties in affecting cell behaviour. In particular, surface topography appears to influence and direct cell migration. The development of new technologies of hot embossing and micro-imprinting has made it possible to study cell interactions with controlled micro features and to determine how these features can affect cell behaviour. Several studies have been carried out on the effect of microstructures on cell adhesion, cell guidance and cell proliferation. However, there is still a lack of knowledge on how these features affect mesenchymal stem cell differentiation. This study was designed to evaluate whether highly controlled microstructures on PMMA could induce rMSC differentiation into an osteogenic lineage. Structured PMMA was seeded with rMSC and cell number; cell morphology and cell differentiation were evaluated. Results confirm that microstructures not only affect cell proliferation and alignment but also have a synergistic effect with osteogenic medium on rMSC differentiation into mature osteoblasts. |
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Authors:
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Elisabeth Engel; Elena Martínez; Chris A Mills; Miriam Funes; Josep A Planell; Josep Samitier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-27 |
Journal Detail:
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Title: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Volume: 191 ISSN: 1618-0402 ISO Abbreviation: Ann. Anat. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-12 Completed Date: 2009-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963897 Medline TA: Ann Anat Country: Germany |
Other Details:
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Languages: eng Pagination: 136-44 Citation Subset: IM |
Affiliation:
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Bio/Non-Bio Interactions for Regenerative Medicine Group, Institute for Bioengineering of Catalonia (IBEC), Josep Samitier 1-5, 08028 Barcelona, Spain. Elisabeth.Engel@upc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells / cytology Cell Count Cell Culture Techniques / methods Cell Differentiation / physiology* Cell Division Culture Media Female Femur Mesenchymal Stem Cells / cytology* Microtechnology / methods* Polymethyl Methacrylate Rats Rats, Wistar Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 9011-14-7/Polymethyl Methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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