Document Detail

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.
MedLine Citation:
PMID:  19085956     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Fetal HSCs, submesothelial cells, and perivascular mesenchymal cells are mesodermal in origin, and ALCAM(+) submesothelial cells may be a precursor for HSCs in developing liver.
Kinji Asahina; Shirley Y Tsai; Peng Li; Mamoru Ishii; Robert E Maxson; Henry M Sucov; Hidekazu Tsukamoto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  49     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-03     Completed Date:  2009-04-01     Revised Date:  2014-11-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  998-1011     Citation Subset:  IM    
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MeSH Terms
Activated-Leukocyte Cell Adhesion Molecule / metabolism
Basic Helix-Loop-Helix Transcription Factors / metabolism
Cell Differentiation / physiology
Cells, Cultured
Desmin / metabolism
Endothelium, Vascular / cytology*,  metabolism
Epithelial Cells / cytology*,  metabolism
Hepatic Stellate Cells / cytology*,  metabolism
Homeodomain Proteins / metabolism
Lac Operon / genetics
Liver / cytology*,  embryology*,  metabolism
Membrane Glycoproteins / metabolism
Mesenchymal Stromal Cells / cytology*,  metabolism
Mice, Transgenic
Organogenesis / physiology*
Receptors, Nerve Growth Factor / metabolism
Grant Support
P50 AA011999/AA/NIAAA NIH HHS; P50 AA011999-09/AA/NIAAA NIH HHS; P50 AA011999-10/AA/NIAAA NIH HHS; P50-AA11999/AA/NIAAA NIH HHS; R24 AA012885/AA/NIAAA NIH HHS; R24 AA012885-06/AA/NIAAA NIH HHS; R24 AA012885-07/AA/NIAAA NIH HHS; R24-AA12885/AA/NIAAA NIH HHS
Reg. No./Substance:
0/Activated-Leukocyte Cell Adhesion Molecule; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Desmin; 0/Gp38 protein, mouse; 0/Homeodomain Proteins; 0/MSX2 protein; 0/Membrane Glycoproteins; 0/Mesp1 protein, mouse; 0/Receptors, Nerve Growth Factor; 0/TNFRSF16 protein, mouse
Comment In:
Hepatology. 2009 Jul;50(1):320; author reply 320   [PMID:  19554539 ]

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