| Mesenchymal stem cells as therapeutics. | |
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MedLine Citation:
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PMID: 20415588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afforded by MSC transplantation are short-lived and related to dynamic, paracrine interactions between MSCs and host cells. Therefore, representations of MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology, therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics. |
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Authors:
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Biju Parekkadan; Jack M Milwid |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of biomedical engineering Volume: 12 ISSN: 1545-4274 ISO Abbreviation: Annu Rev Biomed Eng Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-21 Revised Date: 2011-02-15 |
Medline Journal Info:
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Nlm Unique ID: 100883581 Medline TA: Annu Rev Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 87-117 Citation Subset: IM |
Affiliation:
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Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA. biju_parekkadan@hms.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow / immunology Drug Delivery Systems / methods* Female Hematopoiesis / immunology Humans Inflammation / immunology, therapy* Male Mesenchymal Stem Cell Transplantation* Mesenchymal Stem Cells / immunology, physiology* Mice Multipotent Stem Cells / immunology, physiology*, transplantation* Rats Regenerative Medicine* Tissue Engineering |
| Grant Support | |
ID/Acronym/Agency:
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1K01DK087770-01/DK/NIDDK NIH HHS; K01 DK087770-02/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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