Document Detail


Mesenchymal Stem Cells Restore Orientation and Exploratory Behavior of Rats after Brain Injury.
MedLine Citation:
PMID:  22442818     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We studied the effects of intravenous and intracerebral transplantation of MSC on restoration of orientation and exploratory behavior of Wistar-Kyoto rats after removal of the left motor cortex. Removal of the motor cortex led to a significant reduction of the number of behavioral acts in the open field test. Two weeks after removal of the motor cortex and intravenous transplantation, the animals were as inhibited as the controls, but during the next 10 weeks, the behavioral status of these rats remained unchanged, while controls exhibited further behavioral degradation. After injection of MSC into the brain, the behavior of rats with trauma did not change in comparison with intact rats over 10 weeks.
Authors:
I B Sokolova; O R Fedotova; S G Tsikunov; D G Polyntsev
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  151     ISSN:  1573-8221     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2012-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  -    
Other Details:
Languages:  ENG; RUS     Pagination:  130-132     Citation Subset:  -    
Affiliation:
Trans-Technologies; Institute of Experimental Medicine, North Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia. fedot2003@mail.ru.
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