Document Detail

Mesangial proliferative glomerulonephritis in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  10218320     Owner:  NLM     Status:  MEDLINE    
Ten patients of chronic obstructive pulmonary disease were studied for changes in ultrastructure of the glomeruli, serum immunoglobulin and complement levels. The glomeruli showed proliferation in the mesangium in 90% patients and electron dense deposits in the mesangium in 30% patients. IgA and IgG were usually elevated whereas complements were usually depressed in most of these patients. It is suggested that repeated respiratory infections in these subjects may be responsible for mesangioproliferative type of glomerulonephritis, high IgA and IgG levels. The complements are activated and they take part in immune complex formation getting deposited in mesangium.
D J Dasgupta; I D Garg; S S Kaushal; S Chauhan; A Sharma; A Goyal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  96     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  338-40     Citation Subset:  IM    
Department of Medicine, Indira Gandhi Medical College, Shimla.
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MeSH Terms
Biopsy, Needle
Complement C3 / analysis
Complement C4 / analysis
Glomerulonephritis, Membranoproliferative / etiology,  pathology*
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Kidney Glomerulus / immunology,  ultrastructure*
Lung Diseases, Obstructive / complications*,  pathology
Middle Aged
Reference Values
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Immunoglobulin A; 0/Immunoglobulin G

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