Document Detail

Mesangial glomerulopathy in rheumatoid arthritis patients. Clinical follow-up and relation to antirheumatic therapy.
MedLine Citation:
PMID:  1944747     Owner:  NLM     Status:  MEDLINE    
23 patients (16 women, 7 men) with rheumatoid arthritis (RA) and renal biopsy-proven mesangial glomerulopathy (MGP) were followed for 4-117 months (median 42) in order to evaluate the clinical course of their renal disease. Urinalysis was made, and 24-hour urine protein excretion and serum creatinine were determined. At the time of renal biopsy, the clinical renal findings of the patients were isolated hematuria (n = 10), isolated proteinuria (n = 6) and hematuria combined with proteinuria (n = 7). Hematuria persisted and renal function remained normal in all patients with isolated hematuria. A possible association between the presence of hematuria and the use of antirheumatic drugs was not established in this study. Proteinuria was clinically closely associated with the use of antirheumatic drugs in 9 out of 13 cases (6 with gold sodium thiomalate, 2 with D-penicillamine and 1 with auranofin) suggesting that antirheumatic drugs are important contributors to proteinuria in these patients. Renal function, although initially reduced in some patients, remained stable in all but 1 patient with IgA glomerulonephritis who developed the nephrotic syndrome and died of uremia. In conclusion, the clinical course of MGP in RA patients is benign in most patients. Moreover, this nephropathy may not represent a clinical entity. Proteinuria was related to antirheumatic drugs in most patients whereas microhematuria was constant even after stopping the antirheumatic drugs.
M Korpela; J Mustonen; A Pasternack; H Helin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  59     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-09     Completed Date:  1991-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Department of Clinical, University of Tampere, Finland.
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MeSH Terms
Anti-Inflammatory Agents / adverse effects
Arthritis, Rheumatoid / complications*,  drug therapy
Glomerulonephritis, Membranoproliferative / complications*,  etiology
Hematuria / complications
Middle Aged
Nephrotic Syndrome / complications
Proteinuria / complications
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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