Document Detail

Mesangial cell-glomerular basement membrane connections counteract glomerular capillary and mesangium expansion.
MedLine Citation:
PMID:  2256475     Owner:  NLM     Status:  MEDLINE    
Glomerular capillaries are perfused at a high hydraulic pressure. Since the capillary mesangium interface presents no morphologically apparent pressure barrier, it is suggested that the hydraulic pressure in the mesangium may also be high. This paper analyzes the structures in the glomerular tuft that are capable of counteracting the distending forces exerted on the tuft by the high hydraulic pressure in its center. The skeletal element of the glomerular tuft is the glomerular basement membrane (GBM). The combination of the GBM with the contractile apparatus of mesangial cells represents the main system stabilizing the glomerular tuft. The mesangial cell-GBM connections counteracting the expansion of glomerular capillaries appear less susceptible to injury than those counteracting mesangial expansion.
W Kriz; M Elger; K V Lemley; T Sakai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of nephrology     Volume:  10 Suppl 1     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  4-13     Citation Subset:  IM    
Institut für Anatomie und Zellbiologie, Universität Heidelberg, BRD.
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MeSH Terms
Basement Membrane / ultrastructure
Capillaries / physiology,  ultrastructure
Capillary Permeability / physiology
Glomerular Mesangium / physiology,  ultrastructure*
Kidney Glomerulus / physiology,  ultrastructure*
Microscopy, Electron
Vasodilation / physiology

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